Challenges and Pitfalls in Cytomorphology of Melanoma
Xiaoqi Lin, MD, PhD
Melanoma is a highly aggressive malignant tumor arising from skin, eye, and internal organs. Melanoma frequently metastasizes to lung, liver, the central nervous system, and other diverse sites. Metastasis may be the first clinical presentation in some patients. Melanoma can present with various cytologic patterns including plasmacytoid, undifferentiated, epithelioid, spindle shaped/sarcomatoid, or macrophage-like. The cytoplasm can be delicate, granular, or vacuolated. These cytologic features can potentially mimic carcinoma, plasmacytoma/lymphoma, sarcoma, macrophages, or granular cell tumor, among others. Melanin pigment may be present in some cases, with differentials that include lipofuscin pigments, hemosiderin, or anthracotic pigment. Diagnostically challenging cases with clinical findings, Diff- Quik and/or Papanicolaou stained FNA smears and touch preps, H&E stained cell blocks/cores, and ancillary studies will be presented.
This educational activity is designed for pathologists, cytopathologists, cytotechnologists, students and other members of the cytopathology community.
- Utilize a case based approach to highlight the various cytomorphologic features of melanoma in FNA smears and touch prep of cores.
- Discuss pitfalls and differential diagnosis of melanoma cytology
- Discuss updated target-therapy of melanoma
Xiaoqi Lin, MD, PhD
The presenter has no conflicts of interest or financial relationships to disclose.
Continuing Medical Education (CME) Statement
The American Society of Cytopathology is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The American Society of Cytopathology designates this enduring educational activity for a maximum of 2.0 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
American Board of Pathology Maintenance of Certification (MOC)
This product can help fulfill the CME requirements and Self-Assessment Modules (SAMs) mandated by the American Board of Pathology Maintenance of Certification (MOC) process. Earn up to 2.0 SAM Credit Hours.
Continuing Medical Laboratory Education (CMLE)
The ASC designates this activity for a maximum of 2.0 Continuing Medical Laboratory Education (CMLE) credit hours for non-physicians. The CMLE credit hours meet the continuing education requirements for the ASCP Board of Registry Certification Maintenance Program. Participants should claim only the credit commensurate with the extent of their participation in the activity.
Cytotechnologists with Licenses in Florida and California
This program is approved for 2 continuing education credits in the State of Florida and 1 in the State of California. The credit on each link is good for three years from the live presentation date.
- 2.00 AMA PRA Category 1 Credit™
- 1.00 California Credits
- 2.00 CMLE
- 2.00 Florida Credits
- 2.00 MOC II
- 2.00 Participant